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EVA-PCD® Functional Profile - CPT Code 86849
$3500-$4500 (depending upon quantity/complexity of agents analyzed
)

The EVA-PCD® (Ex Vivo Analysis of Programmed Cell Death) functional profile is a laboratory analysis that exposes patients living tumor cells to chemotherapy drugs/combinations and signal transduction inhibitors (targeted agents). Drug induced cell death (apoptotic & non-apoptotic) is examined by morphology, cytochemistry, staining characteristics and cellular metabolism. Living cells vs dead cells show which drugs kill the cancer cells (sensitive) and which ones do not (resistant). Each patient’s dose response analysis of drug sensitivity, resistance and formal synergy is then compared with Rational Therapeutics’ extensive database and an individualized comprehensive report is generated. Results take 7-10 days from receipt of specimen in the laboratory. Payment is required at the time of service, but as a courtesy we will file a claim with your insurance carrier.

Patient drug panels are disease specific and based on previous treatment history. A typical panel consists of 8 – 16 drugs/combinations and is chosen from the following drug list. Remember that the quantity of drugs analyzed is totally dependent upon the quantity/quality of tumor received in the laboratory.

 

DRUG LIST

 
5-Fluourouracil (Xeloda)
Actinomycin-D
Asparaginase
AZD2281 (PARP)
Bleomycin
BSI201 (PARP)
Carboplatin
Carmustine (BCNU)
Chlorodeoxyadenoasine
(2-CDA)
Cisplatin
Cytarabine (ARA-C)
Dacarabazine (DTIC)
Deoxyazacytidine
Dexamethasone
Docetaxel (Taxotere)
Doxorubicin
Estramustine
Epothilone B (Ixempra)
Etoposide (VP16)
Fludarabine
Geldanamycin
Gemzar (Gemcitabine)
Gleevec (Imatinib)
Interferon-A
Iressa (Gefitinib)
Irinotecan (Camptosar)

Mitomycin-C
Mitoxantrone
Nexavar (Sorafenib)
Nitrogen Mustard
Oxaliplatin
Paclitaxel (Taxol)
Rapamycin (Sirolimus)
Sutent (Sunitinib)

Sprycel (Dasatinib)
Tamoxifen
Tarceva (Erlotinib)
Temodar (TMZ)
Topotecan
Trichostatin A (TSA)
Trimetrexate
Tykerb (Lapatinib)

Velcade (Bortezomib)
Vinblastine
Vincristine
Vinorelbine
Vorinostat (SAHA)
Vinorelbine (Navelbine)
Zactima (Vandetanib)
We are continuously updating our drug compendium with new targeted/investigational agents.
Please contact the laboratory if you have interest in particular agents that are not listed above.

Sample Processing – No analysis $500

On some occasions, we are unable to provide an adequate analysis due to the quantity and/or quality of cells received. There are times when a specimen that is expected to contain malignant cells, may contain too few to setup a reliable evaluation. Under these circumstances, there is a sample processing fee to cover the cost of laboratory personnel, reagents and specimen processing.

Specimen Transportation Kit $100

If a specimen transportation kit is sent out for use and is not returned with a tumor sample for analysis, a charge will apply to cover the cost of supplies, overnight shipping and handling. If a tumor sample is submitted, the cost of the kit is included in the test price.

Third-Party Reimbursement?

Currently, Medicare and most managed care plans do not cover the cost of our laboratory analysis. Some indemnity insurance companies may pay for part or all of our services. The fee for the laboratory assay and/or clinical consultation is required at the time of service. As a courtesy, we will file a claim with your insurance carrier in an attempt to help you recover your out-of-pocket expense.

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